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[Clinical characteristics of 30 medical workers infected with new coronavirus pneumonia].

Identifieur interne : 000108 ( Main/Exploration ); précédent : 000107; suivant : 000109

[Clinical characteristics of 30 medical workers infected with new coronavirus pneumonia].

Auteurs : M. Liu [République populaire de Chine] ; P. He [République populaire de Chine] ; H G Liu [République populaire de Chine] ; X J Wang [République populaire de Chine] ; F J Li [République populaire de Chine] ; S. Chen [République populaire de Chine] ; J. Lin [République populaire de Chine] ; P. Chen [République populaire de Chine] ; J H Liu [République populaire de Chine] ; C H Li [République populaire de Chine]

Source :

RBID : pubmed:32164090

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English descriptors

Abstract

Objective: To investigate the clinical characteristics of medical staff with novel coronavirus pneumonia(NCP). Methods: 30 patients infected with novel coronavirus referred to jianghan university hospital between January 11, 2020 and January 3, 2020 were studied. The data reviewed included those of clinical manifestations, laboratory investigation and Radiographic features. Results: The patients consisted of 10 men and 20 women, including 22 doctors and 8 nurses,aged 21~59 years(mean 35±8 years).They were divided to 26 common type and 4 severe cases, all of whom had close(within 1m) contact with patients infected of novel coronavirus pneumonia. The average contact times were 12 (7,16) and the average cumulative contact time was 2 (1.5,2.7) h.Clinical symptoms of these patients were fever in 23 patients (76.67%) , headache in 16 petients (53.33%) , fatigue or myalgia in 21patients (70%) , nausea, vomiting or diarrhea in 9 petients (30%) , cough in 25 petients (83.33%) , and dyspnea in 14 petients (46.67%) .Routine blood test revealed WBC<4.0×10(9)/L in 8 petients (26.67%) , (4-10) ×10(9)/L in 22 petients (73.33%) , and WBC>4.0×10(9)/L in 4 petients (13.33%) during the disease.Lymphocyte count<1.0×10(9)/L occurred in 12 petients (40%),abnormal liver function in 7 petients (23.33%) ,myocardial damage in 5 petients(16.67%), elevated D-dimer (>0.5mg/l) in 5 patients (16.67%). Compared with normal patients, the average exposure times, cumulative exposure time, BMI, Fever time, white blood cell count, liver enzyme, LDH, myoenzyme and D-dimer were significantly increased in severe patients, while the lymphocyte count and albumin levels in peripheral blood were significantly decreased.Chest CT mainly showed patchy shadows and interstitial changes.According to imaging examination, 11 patients (36.67%) showed Unilateral pneumonia and 19 patients (63.33%) showed bilateral pneumonia,4 patients (13.33%) showed bilateral multiple mottling and ground-glass opacity.Compared with the patients infected in the protected period, the proportion of severe infection and bilateral pneumonia were both increased in the patients infected in unprotected period. Conclusion: Medical staffs are at higher risk of infection.Infection rates are associated with contact time, the amount of suction virus. Severe patients had BMI increased, heating time prolonged, white blood cell count, lymphocyte count, D-dimer and albumin level significantly changed and were prone to be complicated with liver damage and myocardial damage.Strict protection measures is important to prevent infection for medical workers.

DOI: 10.3760/cma.j.issn.1001-0939.2020.03.014
PubMed: 32164090


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<term>Adult</term>
<term>Betacoronavirus (pathogenicity)</term>
<term>Body Mass Index</term>
<term>Coronavirus Infections (complications)</term>
<term>Coronavirus Infections (diagnosis)</term>
<term>Coronavirus Infections (transmission)</term>
<term>Cough (etiology)</term>
<term>Dyspnea (etiology)</term>
<term>Female</term>
<term>Fever (classification)</term>
<term>Fever (etiology)</term>
<term>Fibrin Fibrinogen Degradation Products (analysis)</term>
<term>Health Personnel</term>
<term>Humans</term>
<term>Infectious Disease Transmission, Patient-to-Professional</term>
<term>Leukocyte Count</term>
<term>Liver (pathology)</term>
<term>Lymphocyte Count</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Myocardium (pathology)</term>
<term>Pneumonia, Viral (complications)</term>
<term>Pneumonia, Viral (diagnosis)</term>
<term>Pneumonia, Viral (transmission)</term>
<term>Retrospective Studies</term>
<term>Risk Factors</term>
<term>Serum Albumin</term>
<term>Time Factors</term>
<term>Young Adult</term>
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<term>Facteurs de risque</term>
<term>Facteurs temps</term>
<term>Femelle</term>
<term>Fièvre ()</term>
<term>Fièvre (étiologie)</term>
<term>Foie (anatomopathologie)</term>
<term>Humains</term>
<term>Indice de masse corporelle</term>
<term>Infections à coronavirus ()</term>
<term>Infections à coronavirus (diagnostic)</term>
<term>Infections à coronavirus (transmission)</term>
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<term>Pneumopathie virale (diagnostic)</term>
<term>Pneumopathie virale (transmission)</term>
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<term>Études rétrospectives</term>
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<term>Produits de dégradation de la fibrine et du fibrinogène</term>
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<term>Foie</term>
<term>Myocarde</term>
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<keywords scheme="MESH" qualifier="classification" xml:lang="en">
<term>Fever</term>
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<keywords scheme="MESH" qualifier="complications" xml:lang="en">
<term>Coronavirus Infections</term>
<term>Pneumonia, Viral</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en">
<term>Coronavirus Infections</term>
<term>Pneumonia, Viral</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr">
<term>Infections à coronavirus</term>
<term>Pneumopathie virale</term>
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<keywords scheme="MESH" qualifier="etiology" xml:lang="en">
<term>Cough</term>
<term>Dyspnea</term>
<term>Fever</term>
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<keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en">
<term>Betacoronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en">
<term>Liver</term>
<term>Myocardium</term>
</keywords>
<keywords scheme="MESH" qualifier="transmission" xml:lang="en">
<term>Coronavirus Infections</term>
<term>Pneumonia, Viral</term>
</keywords>
<keywords scheme="MESH" qualifier="étiologie" xml:lang="fr">
<term>Dyspnée</term>
<term>Fièvre</term>
<term>Infections à coronavirus</term>
<term>Pneumopathie virale</term>
<term>Toux</term>
</keywords>
<keywords scheme="MESH" xml:lang="en">
<term>Adult</term>
<term>Body Mass Index</term>
<term>Female</term>
<term>Health Personnel</term>
<term>Humans</term>
<term>Infectious Disease Transmission, Patient-to-Professional</term>
<term>Leukocyte Count</term>
<term>Lymphocyte Count</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Retrospective Studies</term>
<term>Risk Factors</term>
<term>Serum Albumin</term>
<term>Time Factors</term>
<term>Young Adult</term>
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<keywords scheme="MESH" xml:lang="fr">
<term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Facteurs de risque</term>
<term>Facteurs temps</term>
<term>Femelle</term>
<term>Fièvre</term>
<term>Humains</term>
<term>Indice de masse corporelle</term>
<term>Infections à coronavirus</term>
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<term>Mâle</term>
<term>Numération des leucocytes</term>
<term>Numération des lymphocytes</term>
<term>Personnel de santé</term>
<term>Pneumopathie virale</term>
<term>Sérumalbumine</term>
<term>Transmission de maladie infectieuse du patient au professionnel de santé</term>
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<div type="abstract" xml:lang="en">
<b>Objective:</b>
To investigate the clinical characteristics of medical staff with novel coronavirus pneumonia(NCP).
<b>Methods:</b>
30 patients infected with novel coronavirus referred to jianghan university hospital between January 11, 2020 and January 3, 2020 were studied. The data reviewed included those of clinical manifestations, laboratory investigation and Radiographic features.
<b>Results:</b>
The patients consisted of 10 men and 20 women, including 22 doctors and 8 nurses,aged 21~59 years(mean 35±8 years).They were divided to 26 common type and 4 severe cases, all of whom had close(within 1m) contact with patients infected of novel coronavirus pneumonia. The average contact times were 12 (7,16) and the average cumulative contact time was 2 (1.5,2.7) h.Clinical symptoms of these patients were fever in 23 patients (76.67%) , headache in 16 petients (53.33%) , fatigue or myalgia in 21patients (70%) , nausea, vomiting or diarrhea in 9 petients (30%) , cough in 25 petients (83.33%) , and dyspnea in 14 petients (46.67%) .Routine blood test revealed WBC<4.0×10(9)/L in 8 petients (26.67%) , (4-10) ×10(9)/L in 22 petients (73.33%) , and WBC>4.0×10(9)/L in 4 petients (13.33%) during the disease.Lymphocyte coun
<i>t<</i>
1.0×10(9)/L occurred in 12 petients (40%),abnormal liver function in 7 petients (23.33%) ,myocardial damage in 5 petients(16.67%), elevated D-dimer (>0.5mg/l) in 5 patients (16.67%). Compared with normal patients, the average exposure times, cumulative exposure time, BMI, Fever time, white blood cell count, liver enzyme, LDH, myoenzyme and D-dimer were significantly increased in severe patients, while the lymphocyte count and albumin levels in peripheral blood were significantly decreased.Chest CT mainly showed patchy shadows and interstitial changes.According to imaging examination, 11 patients (36.67%) showed Unilateral pneumonia and 19 patients (63.33%) showed bilateral pneumonia,4 patients (13.33%) showed bilateral multiple mottling and ground-glass opacity.Compared with the patients infected in the protected period, the proportion of severe infection and bilateral pneumonia were both increased in the patients infected in unprotected period.
<b>Conclusion:</b>
Medical staffs are at higher risk of infection.Infection rates are associated with contact time, the amount of suction virus. Severe patients had BMI increased, heating time prolonged, white blood cell count, lymphocyte count, D-dimer and albumin level significantly changed and were prone to be complicated with liver damage and myocardial damage.Strict protection measures is important to prevent infection for medical workers.</div>
</front>
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<name sortKey="Liu, M" sort="Liu, M" uniqKey="Liu M" first="M" last="Liu">M. Liu</name>
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<name sortKey="Chen, P" sort="Chen, P" uniqKey="Chen P" first="P" last="Chen">P. Chen</name>
<name sortKey="Chen, S" sort="Chen, S" uniqKey="Chen S" first="S" last="Chen">S. Chen</name>
<name sortKey="He, P" sort="He, P" uniqKey="He P" first="P" last="He">P. He</name>
<name sortKey="Li, C H" sort="Li, C H" uniqKey="Li C" first="C H" last="Li">C H Li</name>
<name sortKey="Li, F J" sort="Li, F J" uniqKey="Li F" first="F J" last="Li">F J Li</name>
<name sortKey="Lin, J" sort="Lin, J" uniqKey="Lin J" first="J" last="Lin">J. Lin</name>
<name sortKey="Liu, H G" sort="Liu, H G" uniqKey="Liu H" first="H G" last="Liu">H G Liu</name>
<name sortKey="Liu, J H" sort="Liu, J H" uniqKey="Liu J" first="J H" last="Liu">J H Liu</name>
<name sortKey="Wang, X J" sort="Wang, X J" uniqKey="Wang X" first="X J" last="Wang">X J Wang</name>
</country>
</tree>
</affiliations>
</record>

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